Professor Kim V-narry of Seoul National University is once again in the headlines producing research results published in the online version of the leading biological journal Cell for the second time in less than two weeks. In her most recent research, Kim and her team proved that the protein Lin-28A is closely involved in suppressing protein expression in stem cells.
Until now, the Lin-28 protein’s only known function was suppression of specific microRNA molecules, which in turn regulate gene expression. In the previous research, the results of which were published in the online version of the Cell on Oct. 12, Kim and her team discovered a previously unknown step in the production of microRNA let-7.
In the latest research, Kim’s team used a technique known as crosslinking immunoprecipitation-sequencing to identify to which RNA molecules the Lin-28A protein binds to in living stem cells. Through the experiment the team discovered that Lin-28A binds not only to microRNA molecules, as previously thought, but also to a large number of RNA molecules involved in protein synthesis that takes place on the surface of the rough endoplasmic reticulum.
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